https://www.nmsociety.org/blog daily 0.75 2025-10-09 https://www.nmsociety.org/blog/read-an-excerpt-from-dr-richard-feinmans-book-nutrition-in-crisis monthly 0.5 2023-02-21 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/77bee7d0-b854-424f-b805-7d939453a673/NMS_BLOG_NIC%2BCover_300dpi.jpg BLOG - Read an Excerpt from Dr. Richard Feinman’s book “Nutrition in Crisis” - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.nmsociety.org/blog/ppf2y5hdtc7w9yuu338kucjzl2ed9b monthly 0.5 2020-09-14 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1599845024122-J50KIEVUOVLS8OVQATFV/07B7A659-C9E4-49FC-9B8A-9E1C7FF5B2E1.jpeg BLOG - A Problem with Medical Journali$m: Feinman Responds https://www.nmsociety.org/blog/keto-diets-for-cancer-part2 monthly 0.5 2025-10-09 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/9840a2f1-812b-4247-9e17-b18f4269250e/KDforCa-2+Figure+1.png BLOG - Ketogenic Diets for Cancer - Part 2. Background on why ketone bodies might help. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.nmsociety.org/blog/keto-diets-for-cancer-part1 monthly 0.5 2025-10-09 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1598994808784-EZ45PY1M4FJXIIXNZSC6/KDfor+Ca+Figure+1.png BLOG - Ketogenic Diets for Cancer - Part 1. “What makes you think that ketone bodies will help?” - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1599061813962-5C1S85SJVE2SOZWTVHT0/KDforCa-1+Figure+2.png BLOG - Ketogenic Diets for Cancer - Part 1. “What makes you think that ketone bodies will help?” - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.nmsociety.org/blog/noakestrial monthly 0.5 2022-10-11 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1594055070516-DDTMVBTK9049Z0BUQZW0/Tim+and+Marika.jpg BLOG - The Noakes Trial, Two Years Later Tim and Marika at a very successful book event. https://www.nmsociety.org/blog/sglt-2-inhibitors-part1 monthly 0.5 2025-10-09 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592865051895-3400VRDB0EFZM6B4X12S/Figure+4+-+ketone+metabolism+in+type+1+diabetes BLOG - Ketogenic Diets, Ketoacidosis, and SGLT-2 Inhibitors - Part 1 With no insulin and, thereby, loss of the ability to turn off fatty acid production, the type 1 patient is at risk for unregulated ketone body production, that is, ketoacidosis (Figure 4). Historically, this was the major threat in diabetes. Because ketoacidosis in the clinic appears in untreated or inadequately controlled type 1, where there is a generally also high blood glucose, there is the expectation that ketoacidosis and hyperglycemia will appear together. The medical literature indicates that, in the case of SGLT-2 where the glucose becomes controlled, acidosis can be missed, and reference is made to “euglycemic ketoacidosis,” but the mechanisms in type 1 and the side effect of SGLT-2 inhibitors are likely the same. It is not the high glucose but, rather, the very low or absent insulin, that is the source of the problem in type 1. (Ketosis is the response to low insulin, and normally, high glucose in a normal person would repress ketosis). Treating diabetes with insulin will allow reinstatement of the controlling feedback loop, but administering external insulin cannot really provide the continuous smooth regulation that keeps blood glucose constant [10]. There remains the possibly of continued fluctuations in blood glucose (and therefore insulin) and that can lead to ketoacidosis. Part 2 will discuss what goes wrong in treatment with SGLT-2 Inhibitors. https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592864450157-ZX8NH0GF3N0WWJ6LXIEF/Figure+1+-+SGLT+illustration BLOG - Ketogenic Diets, Ketoacidosis, and SGLT-2 Inhibitors - Part 1 Humans have evolved multiple mechanisms to insure that blood glucose is maintained at a relatively constant level. Under normal conditions, to prevent excretion of glucose in the urine, the kidney contains proteins that transport the sugar back into the circulation from the tubules (Figure 1). The sodium-glucose transport proteins (SGLTs) and, in particular, the SGLT-2 forms, provide the mechanism for the re-uptake of glucose that has been filtered. In diabetes, the system may not be able to keep up with the high blood glucose. SGLT-2 is a so-called synport or co-transporter, meaning that it carries glucose and sodium together back into the circulation. The energy to drive the transport comes from a sodium gradient created by an an ATP-dependent Na-K exchanger. The idea is that if one can find an inhibitor of the SGLT-2 protein, one can use this system as a strategy for treating diabetes. Several SGLT-2 inhibitors have been developed. This class of drugs blocks the re-uptake allowing glucose to be excreted in the urine [5-7]. The reduction in glucose and the associated reduction in insulin may lead to ketosis (as described below) but, for unknown reasons, this may become excessive. Because the ketone bodies are acids, one of the serious side-effects of SGLT-2 inhibitors is ketoacidosis, the life-threatening effect of unregulated ketosis; an FDA warning was issued in 2015 and recently updated [7]. The punch-line is that ketogenic diets rarely lead to ketoacidosis and, in fact, reduce the need for SGLT-2 inhibitors in patients taking these drugs. https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592864753726-S9VIC4J0BWLMXRU9Y5Q8/Figure+2+-+ketone+body+synthesis BLOG - Ketogenic Diets, Ketoacidosis, and SGLT-2 Inhibitors - Part 1 Under conditions of starvation or low carbohydrate intake, the reduction in insulin (and increase in glucagon) that follows from low glucose leads to breakdown of fat (lipolysis) to fatty acids. Fatty acids then become the major fuel providing acetyl-CoA (the two-carbon fragment that is the essential fuel for oxidative metabolism). Low insulin, in combination with other metabolites, stimulates ketogenesis, the assembly of acetyl-CoA units into the four-carbon ketone bodies, β-hydroxy butyrate (BHB) and acetoacetate (Figure 2). Ketone bodies, made in the liver, are exported to other cells, particularly muscle and brain where they can be turned back into acetyl-CoA and used for energy. Big generalization: the role of ketone bodies is to transport acetyl-CoA from the liver to the periphery. https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592864844722-MCT2P2C5VGP9YSZQBZ57/Figure+3+-+regulation+of+ketosis BLOG - Ketogenic Diets, Ketoacidosis, and SGLT-2 Inhibitors - Part 1 Under normal conditions, the ketone bodies regulate their own synthesis. Ketone bodies can feed back to adipose tissue and repress lipolysis, thereby reducing the supply of fatty acids for synthesis. In addition, ketone bodies stimulate the pancreas to release insulin. (Figure 3) So, normally, there is a long feedback loop: low glucose ➛ low insulin ➛ increase lipolysis ➛ fatty acids ➛ ketone bodies ➛ increase insulin ➛inhibit lipolysis ➛ decrease fatty acids ➛ decrease ketone bodies ➛ low insulin ➛ increase lipolysis, and so on. This is the control system that keeps ketogenic diets from running out of control and prevents acidosis in normal people (Figure 3). This is the system that goes wrong in type 1 diabetes. https://www.nmsociety.org/blog/can-low-carb-decrease-risk-of-serious-illness-from-covid-19 monthly 0.5 2020-06-22 https://www.nmsociety.org/blog/australian-dietitians-association monthly 0.5 2020-06-16 https://www.nmsociety.org/blog/lowcarbdietsrepleteinmicronutrients monthly 0.5 2024-12-19 https://www.nmsociety.org/blog/ketodefinitions monthly 0.5 2024-12-19 https://www.nmsociety.org/blog/failedcrusadeagainstdrnoakes monthly 0.5 2023-02-03 https://www.nmsociety.org/blog/blog-post-title-one-33czf monthly 0.5 2020-05-08 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1588950923254-ELKT25U910DMSTJC6DJO/hewat_claire11474634995-300x224.jpg BLOG - Diet of Worms Claire Hewat, head of DAA. https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1588950988486-PENS3G0M8VKGNHF4TW9Y/diet_aphra_fletcher-1and2.png BLOG - Diet of Worms Martin Fletcher, CEO of AHPRA trying to juggle the truth at the Senate hearing. https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1588950741375-26HK417MACVOIJTBFVFF/diet_luther_worms_vonwerner_1877crop.png BLOG - Diet of Worms Luther at the Diet of Worms https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1588950875625-K1HBWD07Q38WGQ3UIJQG/575707-1449742854.jpg BLOG - Diet of Worms Junker Jörg aka Martin Luther. https://www.nmsociety.org/blog/cholesterolanddrugs monthly 0.5 2024-12-19 https://www.nmsociety.org/blog/bigsugar monthly 0.5 2020-05-02 https://www.nmsociety.org/blog/ketogenic-diets-and-pain monthly 0.5 2024-12-19 https://www.nmsociety.org/blog/brokendietaryguidelines monthly 0.5 2020-05-02 https://www.nmsociety.org/blog/plantbaseddietaryguidelines monthly 0.5 2024-12-19 https://www.nmsociety.org/blog/category/Noakes+Trial monthly 0.5 https://www.nmsociety.org/blog/category/LCHF monthly 0.5 https://www.nmsociety.org/blog/tag/COVID-19 monthly 0.5 https://www.nmsociety.org/blog/tag/Keto monthly 0.5 https://www.nmsociety.org/blog/tag/LCHF monthly 0.5 https://www.nmsociety.org/blog/tag/Corona+Virus monthly 0.5 https://www.nmsociety.org/blog/tag/Low+Carb monthly 0.5 https://www.nmsociety.org/blog/tag/Noakes monthly 0.5 https://www.nmsociety.org/blog/tag/Diabetes monthly 0.5 https://www.nmsociety.org/blog/tag/Medical+advertising monthly 0.5 https://www.nmsociety.org/blog/tag/Ketogenic+diet monthly 0.5 https://www.nmsociety.org/blog/tag/low+carb monthly 0.5 https://www.nmsociety.org/blog/tag/Medical+journalism monthly 0.5 https://www.nmsociety.org/about daily 0.75 2025-10-08 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1590667408320-6AWAANY90VO1C8E3555N/Feinman ABOUT Richard D. Feinman, PhD https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1590667543737-04RRS1U562EAAXKWK0WB/Fine ABOUT Eugene J. Fine, MD https://www.nmsociety.org/sglt-2-part-1 daily 0.75 2025-10-09 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592864450157-ZX8NH0GF3N0WWJ6LXIEF/Figure+1+-+SGLT+illustration Ketogenic Diets, Ketoacidosis and SGLT-2 Inhibitors. https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592864753726-S9VIC4J0BWLMXRU9Y5Q8/Screen+Shot+2020-06-22+at+6.16.57+PM.png Ketogenic Diets, Ketoacidosis and SGLT-2 Inhibitors. https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592864844722-MCT2P2C5VGP9YSZQBZ57/Screen+Shot+2020-06-22+at+6.17.06+PM.png Ketogenic Diets, Ketoacidosis and SGLT-2 Inhibitors. https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592865051895-3400VRDB0EFZM6B4X12S/Screen+Shot+2020-06-22+at+6.17.16+PM.png Ketogenic Diets, Ketoacidosis and SGLT-2 Inhibitors. https://www.nmsociety.org/support-us daily 0.75 2025-05-07 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592321307048-K7N94GQXEWRA5PBV0F88/ebay%2Bpng.jpg SUPPORT US https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1588161572432-YXUN7TCBNQLAK1R03TGF/NMSoc_longevity_final-1024x407.jpg SUPPORT US https://www.nmsociety.org/sglt2-inhibitors-part-2 daily 0.75 2020-09-02 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592865645415-W6C4J681F0J7WTPHHB2D/Screen+Shot+2020-06-22+at+6.38.19+PM.png SGLT-2 INHIBITORS PART 2 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592866659804-Y3ZZNYV9TJ72JOA56DVZ/Screen+Shot+2020-06-22+at+6.38.28+PM.png SGLT-2 INHIBITORS PART 2 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592866106200-EEY9HUU90B48DDLZH0O2/Screen+Shot+2020-06-22+at+6.38.43+PM.png SGLT-2 INHIBITORS PART 2 https://www.nmsociety.org/cells-water-balloons-sponges daily 0.75 2020-07-10 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1594153453026-7HW2D58IVGNJGWLX6YCA/Screen+Shot+2020-07-07+at+4.23.05+PM.png CELLS, WATER, BALLOONS AND SPONGES https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1594153820652-MSZ4SSXUZIV4IF0VW937/Screen+Shot+2020-07-07+at+4.29.33+PM.png CELLS, WATER, BALLOONS AND SPONGES https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1594406915823-U2R666SK6D0PX0Q47X73/Sachs+Figure+2.png CELLS, WATER, BALLOONS AND SPONGES https://www.nmsociety.org/sglt-2-inhibitors-part-2 daily 0.75 2020-07-06 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592866106200-EEY9HUU90B48DDLZH0O2/Screen+Shot+2020-06-22+at+6.38.43+PM.png SGLT-2 INHIBITORS PART 2 (Copy) https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592865645415-W6C4J681F0J7WTPHHB2D/Screen+Shot+2020-06-22+at+6.38.19+PM.png SGLT-2 INHIBITORS PART 2 (Copy) https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/1592866659804-Y3ZZNYV9TJ72JOA56DVZ/Screen+Shot+2020-06-22+at+6.38.28+PM.png SGLT-2 INHIBITORS PART 2 (Copy) https://www.nmsociety.org/contactus daily 0.75 2025-10-31 https://www.nmsociety.org/home daily 1.0 2026-01-08 https://images.squarespace-cdn.com/content/v1/5e6e4b3e9407304bc06b81cd/813ebbcc-2d98-4362-9dc0-b4eac925c9c7/IMG_0967.png